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An Insight Into Acne

More adult women are getting pimples than ever before, according to a study presented last March at the American Academy of Dermatology annual meeting. Today, clinical acne afflicts the complexions of 45 percent of women ages 21 to 30, 26 percent of women ages 31 to 40, and 12 percent of women ages 41 to 50, according to the study, conducted by researchers at Massachusetts General Hospital.
There is no definitive proof that specific foods cause breakouts, but some medical professionals say diet can play a role in keeping clear healthy skin. SkinMed have proven this and reducing sugars and processed carbohydrates and increasing omega oils and boosting immune function do have a role to play. To find out how, please Contact Us

Hormonal induced changes stimulate skin receptors resulting in the skin losing fatty acids including linoleic acid (up to 90% reduction). This causes the rate that the skin loses water to accelerate. The skin tries to control this by producing more skin cells and depositing more keratin inside cells. This thickens up the skin, but it also slows down the water loss. Also the sebaceous glands increase production of sebum (oil). This increases oil on the surface of the skin which also slows down water loss. However this is the start of the problem as the thickening skin layer also causes thickening of the side walls of the sebaceous gland, narrowing it. The increased skin cell production leads to more dead skin cells on the surface, which mix with the increased oil and don’t drop of but block the narrowed opening of the hair follicle duct where the oil from the sebaceous gland is trying to get out. This causes blackheads and white heads, but also cuts off the food supply for bacteria living on the surface of the skin such as p.acnes. The bacteria get under the plug and find this is a much friendlier environment for the bacterial cells to reproduce and divide and grow.

P.acnes bacteria produce an enzyme onto the skin which dissolves the oil coming from the sebaceous gland. The resulting glycerol produced is sucked back in by the bacteria as food. What is left falls of the skin along with normal dead skin cells. However when the bacteria is releasing lipase enzyme under the plug, the waste products which fell off the surface of the skin are trapped under the plug and can trigger the body’s immune response system, which along with the bacteria multiplying, leads to swelling, pus and damage. We now have a potentially scarring swollen pustule (a spot).

It is true that if you don’t get the blockage then you don’t get a spot. So using salicylic acid can help to keep the ducts open. Once closed due to thickening up, the upper skin layer (stratum corneum) doesn’t widen the closed duct opening. It can help soften and remove the plug. It also however thins the skin which is counter productive, as this then increases skin water loss and can exacerbate the situation and make it worse. Also some people allergic to aspirin should not use salicylic acid products and instead should look for products containing pyruvic acid. Aspirin allergy is rare but just using exfoliating solutions such as acids or benzoyl peroxide is not the ideal answer.

P.acnes when being attacked by antibiotics and the body’s immune system like many anaerobic bacteria form a biofilm, whereby the mucous layer surrounding each bacterial cell effectively combines to form one continuous biofilm with all the bacteria in it. They are then protected from antibiotic attack.

So we don’t agree totally with Dr Adams apart from her comments about Accutane (isotretinoin), “Accutane certainly does work I will admit that, once upon a time being touted as the most effective treatment available for severe forms of nodular cystic acne, but the documented side effects include birth defects, depression and severe skin dryness and I don’t usually prescribe it to any of my patients.”

SkinMed utilise Triethyl Citrate combined with GT Peptide 10, which together penetrate the biofilm without destroying it and kill 96% of the bacteria in the biofilm within hours. Other combination treatments break the biofilm and release the bacteria which if not killed quickly will form a new biofilm which is one of the reasons why antibiotic, benzoyl peroxide solutions fail or take a long time to work. By killing the bacteria in the bioflm, they cannot escape. Two studies have been carried out comparing Duac and Aknicare from SkinMed. Aknicare worked faster and was more effective in treating inflamed lesions and reducing oily skin. In another study published in the British Journal of Dermatology, Aknicare cured 86% of hospital presenting acne (acne that had been referred as they had failed on treatment on GP prescriptions, hence they were difficult to treat patients).  


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