Science on Fillast

Hyaluronic Acid and The Skin

The skin is an organ made up of cells as well as simple and complex molecular structures in the area between them to provide structure, send signals from one cell to another, help push cells towards the surface and to hold moisture so that it is available to sustain cells.  This last feature is carried out particularly by a sugar based molecule called hyaluronic acid that is found in both the superficial layer of the skin (the epidermis) and the deeper layer (the dermis) and is made by special cells called fibroblasts.

Hyaluronic acid is able to hold vast amounts of water, making it available as necessary. Moisture saturated hyaluronic acid fibres have a jelly like quality which provides plumpness and firmness to skin. The more you have, the less lines and wrinkles you have.

hyaluronic acid

As we age, fibroblasts slow down and production of hyaluronic acid also decreases, meanwhile existing hyaluronic acid reduces as it is broken down by skin process such as the enzyme hyaluronidase and also by the action of free radicals However the net result is the skin cannot hold as much water and this loss of plumpness causes of lines and wrinkles.

Collagen, Elastin and fibronectine are structural fibres also produced by fibroblasts and provide strength, structure and elasticity to skin. When hyaluronic acid levels are high collagen tends to be produced and remain as short chain, giving a youthful face shape with strong elasticity. Importantly As hyaluronic acid levels deplete in the skin, collagen fibres bind together into thicker more rigid fibres known as Collagen Type-I, leading to an older facial shape. Increasing or maintaining high hyaluronic acid levels can promote or maintain Collagen Type-III

In our mid to late twenties, our collagen is predominantly Collagen Type-III and hyaluronic acid levels are high enough for us not to have wrinkles. It is at this time we should be maintaining and improving hyaluronic acid levels to prevent the beginning of wrinkles and to delay the start of collagen binding.

We can implant or boost hyaluronic acid later in life to fill out wrinkles but we may already have the older face shape due to collagen changes which were triggered by low hyaluronic acid levels. If in later life through peels and lasers we aim to stimulate new collagen and elastin production to increase skin firmness and lift eye brows and sagging mouths etc, it is wise to also boost hyaluronic acid levels before and after to encourage new collagen produced to remain as Type III.

How does Fillast® improve & maintain the amount of Hyaluronic Acid in the skin?

Fillast® has been developed to ensure HA levels remain at a high level through three different mechanisms broadly termed as the "I.S.S. Concept". The I.S.S. concept is described the three parts below.

I = Inhibition of Hyaluronic Acid Breakdown

fucoseThroughout our lives, an enzyme known as hyaluronidase is always present in our skin. It breaks down old molecules of hyaluronic acid which have lost some of their efficacy.
As we age, the fibroblasts produce less and less hyaluronic acid but hyaluronidase continues to reduce existing levels. Over time, this results in decreased levels of hyaluronic acid causing the formation of fine lines and wrinkles as well increasing levels of Collagen Type-I .
One key active ingredient in Fillast is Fucose, which is a sugar that is capable of slowing hyaluronidase activity thereby slowing down the destruction of hyaluronic acid. If Hyaluronic acid has been artificially implanted by injections, Fucose will also help to slow the destruction of this and thereby prolong the effect of injectable fillers. The net result reduces the onset of wrinkles and fine lines. If one can also increase production of hyaluronic acid at the same time then you will achieve a net increase in hyaluronic acid thereby reducing lines and wrinkles and maintaining or promoting a more youthful collagen balance.

Fillast® is the only anti-aging product available on the market
that inhibits hyaluronidase

S = Stimulation of Hyaluronic Acid Biosynthesis

fibroblastsHyaluronic acid is a huge molecule and as such, it cannot penetrate through the skin into lower levels of the skin (the dermis), which is its main area of action in moisture control. As you already know, the fibroblasts produce less and less hyaluronic acid as we age, so how do we get hyaluronic acid into the dermal layer if the molecule is too big?

It is possible to inject hyaluronic acid directly into the dermal layer which is widely done, but ideally you want to increase hyaluronic acid on a constant basis rather than intermittent boosting. Also most people don’t go for injections in their twenties before they have wrinkles, when this is the time you really should be starting to supplement hyaluronic acid levels. The other way is to increase your own fibroblast production. To do this you have to stimulate the fibroblasts into increased activity and then provide them with the raw materials for them to ‘up production’

Hyaluronic Acid is made from two molecules, ‘the raw materials’; Acetylglucosamine and Glucuronic Acid, which are much smaller molecules than hyaluronic acid and with Synchroline patented ‘Oleosome’ technology Fillast® delivers them to the fibroblasts. Fucose – the hyaluronidase enzyme inhibitor mentioned earlier also plays another important role. It speeds up fibroblasts so they take in the raw materials and produce more hyaluronic acid.

So there you have it - protection of existing and boosting of new hyaluronic acid for combined enhancement of hyaluronic acid levels for fewer wrinkles and lines, but we haven’t finished yet! 

Fillast® is one of only a few anti-aging products that
stimulate the biosynthesis of Hyaluronic Acid in the dermal layer

S = Supplementation of Hyaluronic Acid to the Skin

Despite the fact that Hyaluronic Acid is a huge molecule which cannot penetrate to the dermal layer, it does have a benefit and role to play in the superficial layer of the skin, the epidermis. This benefit is seen as a moisturizing and protective effect and is only superficial in nature, but it is used to help older skin cells migrate to the surface to facilitate shedding and cell replacement but it also acts a reservoir providing moisture sustaining these cells. Supplementing this epidermal level will also add to the filling effect being create din the dermal layer.

The vast majority of HA-based anti-aging products only supplement HA to the epidermal layer, where it only has a superficial effect. Fillast® is the only anti-aging product to Supplement, Synthesise and Inhibit the breakdown of HA.

All these three features combine in reducing fine lines and wrinkle depth, promoting a more youthful face shape. Results begin to appear usually after 30 applications. Fillast® plumps the skin by increasing HA levels, unlike other ‘wonder’ creams which work in hours to plump the skin by causing inflammation.