Science behind EnerPeel

Enerpeel® - Chemical Exfoliation Technology

glycolic acidEnerpeel® is a complete program of medical devices designed to perform various types of chemical exfoliation at various skin depths, to exfoliate and stimulate dermal remodelling.

  • Superficial
  • Superficial – medium
  • Medium
  • Medium – deep

Chemical exfoliation is designed for the treatment of several kinds of age-related skin damage and also acts as a prevention factor from damage caused by exposure to UV radiation - including keratinic lesions - which are potentially pre-cancerous.

Treatments as Well as Peels

eyes and lipsEnerpeel® also allows us to introduce other ingredients into the skin to help treat skin issues such as moderating pigmentation. For example:

Enerpeel® Hands is a combined TCA and lactic acid peel which also delivers Kojic acid into the skin to promote the reduction of age and sun spots. Enerpeel® SA delivers salicylic acid to the skin but also delivers the two key active ingredients in Aknicare® to provide a fantastic clinical treatment programme for acne. Enerpeel® Neck (and chest) delivers Pyruvic acid and Lactic acid into the skin but also provides the raw ingredients for hyaluronic acid synthesis. Enerpeel® also supplies TCA 25% and 40%, Revised Jessner’s, Glycolic 70%, Pyruvic 50% and Enerpeel® Eyes and Lips: a TCA/Lactic acid gel for remodelling the eye and lip areas.

Launching in early 2009 will also be Enerpeel® Mandelic Acid for the management of Rosacea and thread veins. So you can now have the right Enerpeel® for complete clinical management of skin issues.

Skin Areas and Indications

Enerpeel® exfoliating medical devices have been developed for a range of specific skin areas including the face, neck, chest and hands; as well the contours around the eyes and lips.

Enerpeel® is also indicated for the following:

Age Related Skin Issues:

actinic keratosisActinic keratosis (also called solar keratosis, or AK) is a premalignant condition of thick, scaly, or crusty patches of skin. It is more common in fair-skinned people, especially those who are frequently exposed to the sun, as it is usually accompanied by solar damage.

Solar elastosis is a degenerative condition which affects the connective tissues of the skin. Normally, the skin undergoes gradual degeneration. Frequent exposure to sunlight or ultraviolet light may accelerate this degenerative process through a process which is termed photo aging.

Solar lentigo is a hyperpigmented lesion caused by exposure to UV light. Solar lentigines are benign, but they do indicate excessive sun exposure, a risk factor for the development of skin cancer.

Alterations of Pigmentation:

Hyperpigmented Lesions are patches of skin that is darker than the surrounding skin. It is a very common condition and usually harmless. An excess production of melanin, the pigment that produces normal skin colour, is the cause.

Melasma is a tan or dark facial skin discoloration. Although it can affect anyone, melasma is particularly common in women - especially pregnant women a- nd those who are taking oral or patch contraceptives or hormone replacement therapy (HRT) medications.

Other Indications:

  • Superficial Scars
  • Radiation Keratosis
  • Acne Vulgaris
  • Acne Scarring
  • Plantar Warts
  • Sebaceous Hyperplasia

 

Chemical Peeling - What is an acid?

hydrogen ion

As defined by Johannes Nicolaus Brønsted and Martin Lowry, an acid is traditionally considered to be any chemical compound that, when dissolved in water, donates a hydrogen ion (H+) to another compound.

proton donor

The Chemical Exfoliating Strength of an Acid Depends on 3 Main Variables:

1) pH

This is the concentration of hydrogen protons present in a solution. The lower the pH, (more acidic) the higher the concentration of dissociated protons.

2) pKa

The strength of an acid is also measured by its pKa which is a measure of how readily an acid molecule gives up its proton into solution. The lower a molecules pKa, the more readily it will give up its proton into solution. So TCA has a very low pKa and this leads to a high level of dissociated protons in solution. Glycolic acid has a higher pKa and hence is less ready to give up (dissociate) its proton into solution and is hence, is less active.

3) Proton Mobility

When dissociated, (parted from their base molecule) the protons attach to water molecules creating oxonium ions such H3O+ or attach to other hydrogen containing molecules. These molecules are unstable and the proton is passed onto other molecules and hence moves through a solution by jumping from one molecule to the next.

Organic Acids

An organic acid is an organic compound with acidic properties. The most common organic acids are the carboxylic acids whose acidity is associated with their CARBOXYL GROUP and its ability to release protons

The strength of an acid is measured by its pKa which can be described as the grip a molecule has on its proton when in solution. The lower the pKa, the stronger is the acid. This is different to pH.

table of acids

How We Electrochemically Measure the Strength of an Acid Solution

The movement of protons in solution depends on the network of water molecules.

The proton interacts with one molecule of water forming the (H30+) oxonium ion.

The Grotthuss Mechanism is the mechanism by which an 'excess' proton diffuses through the network of water molecules (or other hydrogen-bonded liquids) by forming and then breaking bonds with associated water molecules.

grotthuss grotthuss

Chemical Impact of H30+ on Skin Proteins

Peptide link are bonds between peptides making up proteins. Such proteins are found in desmosomes, which are multi protein links between skin cells which hold them in place and also act as signaling pathways between cells. Protons can break these bonds - and thus break the desmosomes – which leads to the detachment of skin cells (skin shedding), thus increasing skin cell turnover.

oxonium

The breakdown of desmosomes results in detachment of keratinocytes
and therefore enhances epidermal cellular turnover.

oxonium impact

Enerpeel® Carrier Solution Technology - The Sleeping Proton Concept

An acidic solution using Enerpeel® Technology results in a reduced mobility of protons. This means that the previously mentioned Grotthuss movement is slowed down. This restrains the protons’ activity and makes it easier to get the molecules into the skin.

The positive and negative charges are effectively ‘isolated’ and do not interact with polar charges on and in the skin allowing the molecules to diffuse into and through the skin surface, giving a greater and more uniform absorption of 2 to 3 times more than in a standard acid solution.

When the Enerpeel® Technology solution enters the skin and comes into contact with positive and negative (polar) skin structures and molecules, the protons are ‘released’ and ‘break free’ of the Enerpeel® restraint on their mobility and they accelerate through intercellular and cellular structures, achieving much greater mobility and hence interact in a stronger but more precise way on these structures. These structures include water, proteins and chemical links within organized structures such as desmosomes. The result is a more effective and efficient chemo-exfoliation.

By reducing surface activity and accelerating the peeling activity of the protons in the skin, Enerpeel® achieves highly effective chemical remodelling at the dermal level, while reducing surface trauma by:

  • Stimulating fibroblasts to increase production of new skin fibres such as collagen and hyaluronic acid
  • Triggering enzymes such as matrix metalloproteases to break down the old fibrous structures

peeling process

More Homogenous Absorption

The absorption of polar structures into the skin is difficult. Skin lipids represent a barrier to the absorption of dissociated organic acids due to positive and negative charges in the skin.

homogeous

To Read More About the Individual Products in the Enerpeel Range, Click Here