Clinical Considerations with Thiospot® (New Improved Formula)

Thiospot IntensiveThiospot® is a safe alternative to banned and existing products that have been available since early 2001. Thiospot® is a combination of a natural chemical called Thioctic acid, Linoleic acid and Octadecanedioic acid. We all make our own Thiotic acid, which is used to generate energy in our cells. Lactic (Cream) or salicylic (skin roller) acid is present as an exfoliant to encourage lighter cells to come to the surface quicker.

All the key ingredients have a synergistic effect on Melanin manufacture. Absorption into the skin is critical to effectiveness. It is only with recent patented advances in formulations that one can now get products to the right skin depth where they can be effective in reducing pigmentation problems.

Remember, Thiospot® does not contain Hydroquinone, Arbutin or Bearberry.


The exact incidence of chloasma is unknown, but it is a common condition with a female to male predilection, with a ratio of 9:12. It is common in Asians and Hispanics. Chloasma occurs commonly in pregnancy. One study found a prevalence among 400 pregnant patients of 15.8%.3 It is rare before puberty and is commonest in women during their reproductive years. It is also linked to use of oral contraceptives.

One study of patients with chloasma found that the frequency of thyroid disorders was four times greater compared to a control group. Sun exposure is a well established risk factor and Chloasma occurs in sun-exposed areas of the skin. 30% of patients report a family history, and identical twins with chloasma have been reported.

Usually develops as a gradual onset on areas of dark skin. The colour may vary from tan to brown, but may be black or have a bluish tinge. The distribution is usually symmetrical. Three patterns are commonly seen - centrofacial, malar or mandibular. Wood's light helps to locate the pigmentation in the dermis or epidermis. In many cases, it is found in both locations.

Chloasma is a difficult condition to manage, as sunlight is a considerable aggravating factor and it is difficult to prevent exposure even with high factor protection creams. A variety of treatment approaches have been tried. The most effective historically seems to be the use of lightening agents. Hydroxyquinone is the most commonest used but has now associated side effect risks becoming more apparent.

Other lightening agents that have been tried include tretinoic acid, ascorbic acid, kojic, azelaic acid, Thioctic Acid either alone or in combination.

Laser treatment and intense pulse light therapy is also sometimes employed to hasten resolution. Sometimes a peeling agent such as lactic acid is used as this can also reduce melanin synthesis.