Recovery After Burns

Annals of Burns and Fire Disasters - vol. X - n. 3 - September 1997

Dermofunctional Treatment of Hypertrophic Burn Scars
P. De Santis, A. Savoia,
Department of Plastic Surgery and Burn Unit, Brindisi, Italy


A review of the pathology of hypertrophic burns was discussed and followed by an analysis of the results of a study of twenty consecutive patients with hypertrophic burn scars. The patients were treated with Terproline®, a cream compound consisting of an association of functional substances capable of stimulating the biosynthesis of the macromolecules responsible for skin pliability and elasticity

The criteria for the selection of patients were the presence of deep hypertrophic burn scars, an average burned surface of 20%, and the use of pressure garment therapy.

Each patient treated was matched with a control group patient selected among patients treated by other physicians working in the same Burns Unit. The patients were matched for age group, scar site, and duration of treatment with hydrating creams and pressure garments.

All the patients were followed up monthly and the scar was assessed by a physician in the Burns Unit who was unaware of the patients' which study group the patient belonged to.

The following scar characteristics were assessed:
appearance, consistency, presence of nodules, coloration, and presence of ulcers.

One patient underwent two hypertrophic scar biopsies: at the beginning of treatment and after six months. Our results indicate that hypertrophic scars in the Terproline® group were more elastic and pliable at six months than those in the hydrating cream group.

The effect of Terproline ® as a precursor and stimulator of hyaluronic acid, fibronectine and soluble collagen biosynthesis is discussed.

Results and Conclusions

The two groups of patients were comparable as regards their main characteristics. Scar evaluation results at six months are presented in the Table.
The hypertrophic scars of the Terproline-treated patients were more pliable and elastic than those in the hydrating cream group.

This early and better response may be due to the effect of the association of key molecular substances for the production of hyaluronic acid, fibronectine, and soluble collagen.

Patient With Hypertrophic Burn Scar In The Right Shoulder (after 6 months)

Elastocompressive & Topical Therapy Initiated - 2 Weeks After Healing

Below are the histological biopsies taken of the hypertrophic scars in two patients one after treatment with Terproline®, the other being treated with hydrating cream. The biopsies were stained to show the distribution of elastic fibres and one can see a significant difference in the level and distribution of elastin fibres (shown by black threads).