Clinical - The Pre–Post Utilization of Terproline® in Laser Skin Resurfacing & Chemical Peels

Erythema After Aesthetic Laser Surgery

A solution for this problem with a new treatment concept
Department of Plastic Surgery, Burns and Hand Surgery,  Kliniken Merhcim, Cologne

Purpose of the Study

The purpose of this study was to investigate the effect of a new wound management in combination with a local application of Terproline® cream after ultrapulse carbon laser skin resurfacing. The standardized study parameters were pain, skin coating (scabs or crusts), wrinkle reduction, erythema and skin quality.

Patients and Methods

During the period of time December 1996 until March 1997 we examined 49 female and 3 male patients who underwent a ultra pulse carbon Laser surgery. The basic treatment concept included a antibiotic and antiviral prophylaxis with a wound management following surgery. We had 4 randomized groups consisting of 13 patients.

  • Group 1 (identified by a green circle in the chart below) applied Terproline® 4 weeks before surgery

  • Group 2 (gray triangle) for 2 weeks before surgery;

  • Group 3 (pink square) was operated without preoperative Terproline® treatment

    • All 3 of these groups kept on using the cream after 8-10 days postoperatively.

  • Group 4 didn't’t apply any Terproline before or after surgery. Normal moisturization was used.

In regards to the study parameters, individual responses were evaluated independently by a standardized methodology at the 3rd and 8th day as well a follow up 2,3,5,7 and 10 weeks after surgery. A change of colour was measured by a photometric system simultaneously.


No incidence of scarring, infections or pigmented changes were noted on our patient groups. All individuals demonstrated a smoother dermal texture and a reduction of the wrinkle depth between 50-80%. The groups 1-3 who have been treated with Terproline® were had better results in different measured parameters.

Post operative pain sensation

80-100% of the patients who were pro operative treated with Terproline® reported no pain, However almost 40% of the pre operative non treated patients reported a moderate to severe sensation of pain.

Skin Tension

A similar distribution was reported in regards in subjective feeling of skin tension.
Patients with a pro-operative Terproline® application reported some only minor tension up to 8 days after surgery, while 70% of the patients in the group without preoperative application of the substance complained about major tightness during the same period.


The wounds of the patients with pre-operative Terproline® treatment were well healed within two weeks without irritations or scabs.
The un-pretreated group had partial adherent or loose scabs or crust.

Return to Normal Routine

It was noted that the patients in groups 2T/T and 4T/T were able to cover the treated area with make-up after 10 and 14 days respectively and return to work, whereas the conditions of the groups without Terproline®  treatment didn't’t allow them to go back to work for much longer.


The most obvious difference was noted at the post operative erythema. We found a significant difference in regards to the reduction of the redness with the Terproline® treatment. In every spectrophotometric measurement the groups I-III had less erythema compared to the group without cream application, in many cases the erythema was completely vanished whereas in 1/4 of group IV the skin was still visibly red.

Groups green and gray achieved ‘normal’ skin colour in approximately 3 weeks whereas the average for the blue group was 10 weeks

Clinical Graph


Skin resurfacing by laser has become an important role in the field of aesthetic surgery. To refine the texture and increase the strength of the skin, reducing the depth of wrinkles by 50-80% leads an individual to look younger. In this study we demonstrated that it is possible to reduce some of the more troubling side effects of pain, tension and especially postoperative erythema, by including Terproline®  cream in pre treatment and post-operative management.